反应详情

A suspension of 2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine (600 mg., 2 mmoles), iodine (420 mg., 3.2 mmoles) and potassium iodate (180 mg., 0.8 mmole) in 60% aqueous acetic acid (50 ml.) containing 2 ml. of concentrated sulfuric acid is stirred at room temperature for 48 hours. The solution is diluted with ice water and the pH adjusted to 8 with aqueous sodium bicarbonate. The reaction mixture is extracted with dichloromethane and the dried extracts are evaporated in vacuo to yield 3-iodo-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine.

1. additioncontaining 2 ml
2. extractionThe reaction mixture is extracted with dichloromethane
3. customthe dried extracts are evaporated in vacuo