Hydrogen Bromide → HCID 178419741, compound

HRID 1413440Notes

Reaction equation

HRID 1413440 reaction equation
[Cl:1][C:2]1[C:3]([O:16]C)=[CH:4][C:5]([O:14]C)=[C:6]([N:8]=[C:9]2[NH:13][CH2:12][CH2:11][NH:10]2)[CH:7]=1.[BrH:18]>>[BrH:18].[Cl:1][C:2]1[C:3]([OH:16])=[CH:4][C:5]([OH:14])=[C:6]([N:8]=[C:9]2[NH:10][CH2:11][CH2:12][NH:13]2)[CH:7]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 178493527HCID 178493527, compound

Product 1

HCID 178419741HCID 178419741, compoundYield 60.5%

Procedure

A mixture of 10 gm of 2-(5-chloro-2,4-dimethoxy-phenylimino)-imidazolidine (0.03 mol) and 150 ml of 48% hydrobromic acid was refluxed for six hours. Thereafter, the clear, homogeneous reaction mixture was allowed to stand overnight in the refrigerator. The crystalline precipitate which had formed was collected by suction filtration, washed with ether and dried, yielding 5.6 gm (60.5% of theory) of 2-(5-chloro-2,4-dihydroxy-phenylimino)-imidazolidine hydrobromide, Rf -value 0.5 in mobile phase 75 parts sec.butanol, 15 parts formic acid, 10 parts water. Carrier: silicagel; visualization: potassium iodoplatinate.

Workup

  1. temperaturewas refluxed for six hours
  2. customThe crystalline precipitate which had formed
  3. filtrationwas collected by suction filtration
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-97385e6e3c5e4ae29790e61a5271a7de
Source dataset
uspto-grants-1981_02
Patent number
US04250186

Reaction notes

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