Hydrogen Bromide → HCID 178419510, compound

HRID 1413441Notes

Reaction equation

HRID 1413441 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([N:10]=[C:11]2[NH:15][CH2:14][CH2:13][NH:12]2)[CH:6]=[CH:7][C:8]=1[CH3:9].[BrH:16]>>[BrH:16].[OH:2][C:3]1[CH:4]=[C:5]([N:10]=[C:11]2[NH:12][CH2:13][CH2:14][NH:15]2)[CH:6]=[CH:7][C:8]=1[CH3:9]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 178493078HCID 178493078, compound

Product 1

HCID 178419510HCID 178419510, compound

Procedure

A mixture of 6.61 gm of 2-(3-methoxy-4-methylphenylimino)-imidazolidine base (0.032 mol) and 100 ml of 48% hydrobromic acid was refluxed for 12 hours while stirring. Thereafter, the hydrobromic acid was evaporated in value, the residue was dissolved in methanol, the solution was filtered, and ether was added to the filtrate. The crystalline precipitate formed thereby was collected by suction filtration, washed with ether and dried. Yield: 4.85 gm (55.65% of theory) of 2-(3-hydroxy-4-methyl-phenylimino)-imidazolidine hydrobromide, m.p. 164°-165° C., Rf -value 0.4 in mobile phase 75 parts sec. butanol, 15 parts formic acid, 10 parts water. Carrier: silicagel with fluorescent pigment ZS; visualization: ultraviolet light and potassium iodoplatinate.

Workup

  1. temperaturewas refluxed for 12 hours
  2. customThereafter, the hydrobromic acid was evaporated in value
  3. dissolutionthe residue was dissolved in methanol
  4. filtrationthe solution was filtered
  5. additionether was added to the filtrate
  6. customThe crystalline precipitate formed
  7. filtrationthereby was collected by suction filtration
  8. washwashed with ether
  9. customdried

Sources & evidence

ORD record
ord-fcd40ff09835458aa43e40be8023701d
Source dataset
uspto-grants-1981_02
Patent number
US04250186

Reaction notes

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