反应详情

温度

140 °C

A mixture of 17.3 parts of 1-(ethoxycarbonyl)-4-hydroxypiperidine, 24.7 parts of bromodiphenylmethane and 7 parts of potassium carbonate is stirred and heated in an oil-bath for 3 hours at 140° C. The reaction mixture is cooled, water is added and the product is extracted with methylbenzene. The extract is washed a few times with water, dried, filtered and evaporated. The oily residue is distilled, yielding ethyl 4-(diphenylmethoxy)-1-piperidinecarboxylate; bp. 150° C. at 0.4 mm. pressure.

1. temperatureThe reaction mixture is cooled
2. extractionthe product is extracted with methylbenzene
3. washThe extract is washed a few times with water
4. customdried
5. filtrationfiltered
6. customevaporated
7. distillationThe oily residue is distilled