反应详情

A mixture of 12 parts of methyl [1-{3-[4-(diphenylmethyl)-1-piperazinyl]propyl}-1H-benzimidazol-2-yl]carbamate, 60 parts of a concentrated hydrochloric acid solution and 80 parts of ethanol is stirred and refluxed overnight. The reaction mixture is evaporated and water is added to the residue. The free base is liberated in the conventional manner with ammonium hydroxide and extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from ethanol. The product is filtered off and dried, yielding 1-{3-[4-(diphenylmethyl)-1-piperazinyl]propyl}-1H-benzimidazol-2-amine; mp. 228.7° C.

1. temperaturerefluxed overnight
2. customThe reaction mixture is evaporated
3. additionwater is added to the residue
4. extractionextracted with trichloromethane
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated
8. customThe residue is crystallized from ethanol
9. filtrationThe product is filtered off
10. customdried