HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutylamine → 2-(3-chlorophenoxy)N-isobutylnicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutylamine | HCID 6558 | — |
| Reactant | 2-(3-Chlorophenoxy)nicotinoyl chloride | HCID 22612112 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(3-chlorophenoxy)N-isobutylnicotinamide | HCID 20290269 | — |
Reaction Steps
In the same manner as in Example 1(c) 1.4 grams (0.02 mole) isobutylamine and 2.7 grams (0.01 mole) of the acyl chloride produced in step (b) were combined in 50 milliliters toluene to yield 2.8 grams (92.1% of theoretical yield) of the desired product, m.p. 86°-87° C. The structure was confirmed by mass spectrometry.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04251263 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-5ca4ef4a074943e2a50da4c8c1a9315b |
| Source note | uspto-grants-1981_02 |