反应详情

温度

25 °C

To a solution of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (5.0 g., 0.028 M) and sodium hydroxide (2.26 g., 0.056 M) in water (100 ml.) at 10° C. is slowly added 3-bromopropionyl chloride (2.84 ml., 0.028 M). This mixture is stirred at 25° C. overnight. Potassium thiolacetate, prepared by mixing thiolacetic acid (3.00 ml., 0.042 M) and potassium carbonate (3.90 g., 0.028 M) in water (30 ml.), is added to the reaction mixture which is stirred at 25° C. overnight to yield the title compound as an alkali metal salt. Acidification with dilute hydrochloric acid affords the free carboxylic acid.

1. customat 10° C.
2. additionis added to the reaction mixture which
3. stirringis stirred at 25° C. overnight