Hydrogen Bromide → HCID 86737498, compound

HRID 1413729Notes

Reaction equation

HRID 1413729 reaction equation
C([NH:11][CH2:12][C:13]([NH:15][C:16]([C:24]([N:26]1[CH2:31][CH2:30][NH:29][C:28](=[O:32])[CH:27]1[CH2:33][CH:34]([CH3:36])[CH3:35])=[O:25])=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:14])(OCC1C=CC=CC=1)=O.Br>C(O)(=O)C>[NH2:11][CH2:12][C:13]([NH:15][C:16]([C:24]([N:26]1[CH2:31][CH2:30][NH:29][C:28](=[O:32])[CH:27]1[CH2:33][CH:34]([CH3:36])[CH3:35])=[O:25])=[CH:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:14]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 86737499HCID 86737499, compound

Product 1

HCID 86737498HCID 86737498, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4-[N-carbobenzyloxyglycyldehydrophenylalanyl]-3-(2-methylpropyl)piperazinone (XXXVI, Example 69, 0.5 g.) is added to a solution of hydrogen bromide (32%) in acetic acid (5 ml.). After 1 hour the diluents are evaporated to give the title compound as the hydrobromide salt.

Workup

  1. customAfter 1 hour the diluents are evaporated

Sources & evidence

ORD record
ord-d3fb964b872941c0bf0645d59ad2f8ca
Source dataset
uspto-grants-1981_02
Patent number
US04251438

Reaction notes

Loading…