Ethanol → HCID 20495826, compound

HRID 1413802Notes

Reaction equation

HRID 1413802 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[Cl:27])[CH2:5][N:6]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:13]2[C:8](=[C:9](F)[CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:23].[Na].[CH2:29]([OH:31])[CH3:30]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[Cl:27])[CH2:5][N:6]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:13]2[C:8](=[C:9]([O:31][CH2:29][CH3:30])[CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:23]

Participants

4

Reactant 3

HCID 702EthanolHCID 5360545SodiumHCID 20495831HCID 20495831, compound

Product 1

HCID 20495826HCID 20495826, compound

Procedure

Ethyl 2-(3,4-dichlorobenzyl)-8-fluoro-1,2-dihydro-1-oxophthalazin-4-ylacetate (1.8 g.) was added to a solution of sodium (1.5 g.) in dry ethanol (150 ml.). The solution obtained was heated under reflux for 3 hours and then evaporated. Water (100 ml.) was added to the residue and the solid obtained was collected by filtration and dried to give ethyl 2(3,4-dichlorobenzyl)-8-ethoxy-1,2-dihydro-1-oxophthalazin-4-ylacetate (0.5 g.).

Workup

  1. customThe solution obtained
  2. temperaturewas heated
  3. temperatureunder reflux for 3 hours
  4. customevaporated
  5. additionWater (100 ml.) was added to the residue
  6. customthe solid obtained
  7. filtrationwas collected by filtration
  8. customdried

Sources & evidence

ORD record
ord-bbeadbb79fda4764ade62b5b639ee1b8
Source dataset
uspto-grants-1981_02
Patent number
US04251528

Reaction notes

Loading…