Diethyl Ether → HCID 20290839, compound

HRID 1413805Notes

Reaction equation

HRID 1413805 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[O:10])=[CH:4][CH:3]=1.CCOCC.[Br:21]Br>C(Cl)Cl>[Br:21][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[C:9]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)=[O:10]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 12751641HCID 12751641, compound

Product 1

HCID 20290839HCID 20290839, compoundYield 101.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 94.1 g (0.43 mole) of 2-(4-fluorophenyl)-1-(2-thienyl)ethanone in 700 ml. of ether was added dropwise a solution of 65.0 g. (0.41 mole of bromine in 140 ml. of methylene chloride at room temperature with stirring. The solvent was removed under vacuum to give 125.0 g of 2-bromo-2-(4-fluorophenyl)-1-(2-thienyl)ethanone.

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-65b951d330014c6e8325b1556d6c3dde
Source dataset
uspto-grants-1981_02
Patent number
US04251535

Reaction notes

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