2-Aminophenol → HCID 20290821, compound

HRID 1413816Notes

Reaction equation

HRID 1413816 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[CH:9]([F:16])([F:15])[C:10]([CH:12]([F:14])[F:13])=[O:11]>C1(C)C=CC=CC=1>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:10]([OH:11])([CH:9]([F:16])[F:15])[CH:12]([F:14])[F:13])=[CH:4][C:3]=1[OH:8]

Participants

4

Reactant 2

HCID 58012-AminophenolHCID 677582-Propanone, 1,1,3,3-tetrafluoro-

Product 1

HCID 20290821HCID 20290821, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2-amino-hydroxybenzene, toluene and sym-tetrafluoroacetone can be heated in a Hastelloy® bomb. The solvent can be removed by evaporation and the residual material can be purified by chromatography on silica gel to give 4-amino[2,2-difluoro-1-hydroxy-1-(difluoromethyl)ethyl]-3-hydroxybenzene.

Workup

  1. customThe solvent can be removed by evaporation
  2. customthe residual material can be purified by chromatography on silica gel

Sources & evidence

ORD record
ord-bd3244e06be84743a1531bec8eda11ee
Source dataset
uspto-grants-1981_02
Patent number
US04251534

Reaction notes

Loading…