2-(4-(3-Methyl-2-butenyl)phenyl)propionic acid → HCID 20291061, compound

HRID 1413835Notes

Reaction equation

HRID 1413835 reaction equation
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:8][CH:7]=1)[CH:2]=[C:3]([CH3:5])[CH3:4].[Cl-].[Ca+2:18].[Cl-].[Ca]>[OH-].[Na+]>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([CH:12]([CH3:16])[C:13]([O-:15])=[O:14])=[CH:10][CH:11]=1)[CH:2]=[C:3]([CH3:5])[CH3:4].[Ca+2:18].[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([CH:12]([CH3:16])[C:13]([O-:15])=[O:14])=[CH:10][CH:11]=1)[CH:2]=[C:3]([CH3:5])[CH3:4]

Participants

5

Reactant 3

HCID 1754602-(4-(3-Methyl-2-butenyl)phenyl)propionic acidHCID 5284359Calcium ChlorideHCID 5460341Calcium

Product 1

HCID 20291061HCID 20291061, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4.8 g of 2-(p-prenylphenyl)propionic acid as prepared in Example 1 was dissolved in 5% aqueous sodium hydroxide solution to adjust to pH 9.0. To the solution, 5% aqueous calcium chloride solution was added dropwise until the insoluble calcium salt no longer formed. The aqueous layer was decanted and the residual solid was crystallized from methanol to give 4.2 g of calcium 2-(p-prenylphenyl)propionate, colorless needles, m.p. 64°-65° C.

Workup

  1. customno longer formed
  2. customThe aqueous layer was decanted
  3. customthe residual solid was crystallized from methanol

Sources & evidence

ORD record
ord-c7d9c43890894c72805e3cf6d59d6cdc
Source dataset
uspto-grants-1981_02
Patent number
US04251543

Reaction notes

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