Tert-Butylamine → 3-Ethyl-5-[2-(2-hydroxy-3-tert.-butylaminopropoxy)-styryl]-isoxazole

HRID 1413846Notes

Reaction equation

HRID 1413846 reaction equation
[CH2:1]([C:3]1[CH:7]=[C:6]([CH:8]=[CH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][CH:18]2[O:20][CH2:19]2)[O:5][N:4]=1)[CH3:2].[C:21]([NH2:25])([CH3:24])([CH3:23])[CH3:22]>>[CH2:1]([C:3]1[CH:7]=[C:6]([CH:8]=[CH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][CH:18]([OH:20])[CH2:19][NH:25][C:21]([CH3:24])([CH3:23])[CH3:22])[O:5][N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 544596603-Ethyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole

Product 1

HCID 543216963-Ethyl-5-[2-(2-hydroxy-3-tert.-butylaminopropoxy)-styryl]-isoxazole

Procedure

7 g (0.026 mole) of 3-ethyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole and 3.0 g (0.04 mole) of tert.-butylamine are reacted by the method described for Example 4. 6.6 g (66% of theory), melting point 163°-164° C.

Sources & evidence

ORD record
ord-7aaf053cb0d843348a5498f70b3f7beb
Source dataset
uspto-grants-1981_02
Patent number
US04251539

Reaction notes

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