Cyclopropylamine → 3-Isopropyl-5-[2-(2-hydroxy-3-cyclopropylaminopropoxy)-styryl]-isoxazole

HRID 1413847Notes

Reaction equation

HRID 1413847 reaction equation
[CH:1]([C:4]1[CH:8]=[C:7]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH:19]2[O:21][CH2:20]2)[O:6][N:5]=1)([CH3:3])[CH3:2].[CH:22]1([NH2:25])[CH2:24][CH2:23]1>>[CH:1]([C:4]1[CH:8]=[C:7]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH:19]([OH:21])[CH2:20][NH:25][CH:22]2[CH2:24][CH2:23]2)[O:6][N:5]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 544590543-Isopropyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole

Product 1

HCID 538841093-Isopropyl-5-[2-(2-hydroxy-3-cyclopropylaminopropoxy)-styryl]-isoxazole

Procedure

7 g (0.025 mole) of 3-isopropyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole and 3 g (0.05 mole) of cyclopropylamine are reacted by the method described in Example 5. 3.0 g (30% of theory) of colorless crystals are obtained as the fumurate. Melting point 148°-152° C.

Workup

  1. custom3.0 g (30% of theory) of colorless crystals are obtained as the fumurate

Sources & evidence

ORD record
ord-54f5162ebc9e46818ce63167d55584e0
Source dataset
uspto-grants-1981_02
Patent number
US04251539

Reaction notes

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