4-Chlorophenol → 2-(5-Chloro-2-hydroxyphenyl)-2-(5-chloro-2-methoxyphenyl)propane

HRID 1413862Notes

Reaction equation

HRID 1413862 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([C:8](O)([CH3:10])[CH3:9])[CH:7]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1.FC1C=CC(O)=C(C(C2C=C(F)C=CC=2OC)(C)C)C=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([C:8]([C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[O:12][CH3:13])([CH3:10])[CH3:9])[CH:16]=1

Participants

4

Reactant 3

HCID 46844-ChlorophenolHCID 202910912-(5-Fluoro-2-hydroxyphenyl)-2-(5-fluoro-2-methoxyphenyl)propaneHCID 202911052-(5-Chloro-2-methoxyphenyl)propan-2-ol

Product 1

HCID 202911142-(5-Chloro-2-hydroxyphenyl)-2-(5-chloro-2-methoxyphenyl)propane

Procedure

2-(5-chloro-2-hydroxyphenyl)-2-(5-chloro-2-methoxyphenyl) propane (m.p. 137° C.) was prepared from 2-(5-chloro-2-methoxyphenyl)propan-2-ol and 4-chlorophenol following the method described in Example 3 for the preparation of 2-(5-fluoro-2-hydroxyphenyl)-2-(5-fluoro-2-methoxyphenyl)propane.

Sources & evidence

ORD record
ord-6a33eeeee34346009ee5193aa9305b46
Source dataset
uspto-grants-1981_02
Patent number
US04251546

Reaction notes

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