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HRID1413874

反应详情

EQUATION

反应方程式

HRID 1413874 的结构方程式

REACTANTS

反应物

2
结构：CCn1c(C)cc2ccccc21
HCID170432

1H-Indole, 1-ethyl-2-methyl-

C11H13N

结构：O=C1OC(=O)c2cc([N+](=O)[O-])ccc21
HCID230976

4-Nitrophthalic anhydride

C8H3NO5

PRODUCTS

生成物

1
结构：CCn1c(C)c(C(=O)c2ccc([N+](=O)[O-])cc2C(=O)O)c2ccccc21
HCID20523561

2-(1-Ethyl-2-methyl-1H-indole-3-carbonyl)-5-nitrobenzoic acid

C19H16N2O5

收率 57.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

A solution of 67.2 g (0.4 mole) of 4-nitrophthalic anhydride and 63.0 g (0.32 mole) of 80.6 percent active 1-ethyl-2-methylindole in 50 ml of ethylene dichloride was heated at reflux for two hours. The reaction mixture was then allowed to cool to room temperature. The yellow precipitate which separated was collected by filtration, washed with fresh ethylene dichloride and dried to obtain 64.5 g of 2-[(1-ethyl-2-methyl-3-indolyl)carbonyl]-5-nitrobenzoic acid (Formula VIII: R0 =R2 =R3 =Y1 =H; R1 =NO2 ; R5 =CH3 ; R6 =CH2CH3) having a melting point of 203°-204° C.

WORKUP

后处理

  1. temperatureat reflux for two hours
  2. customThe yellow precipitate which separated
  3. filtrationwas collected by filtration
  4. washwashed with fresh ethylene dichloride
  5. customdried