反应详情

A solution of 20.0 g (0.08 mole) of 4-diphenylmethylpiperidine, 14.2 g (0.16 mole) of N,N-dimethylthioformamide and 50 ml of toluene was refluxed for 12 hours, cooled, and washed with water. The organic layer was separated, dried and stripped to an oil which was treated with diethyl ether to give a solid. Recrystallization of this material afforded a white crystalline solid, 4-(diphenylmethyl)-1-piperidinecarbothioaldehyde, m.p. 152°-154° C.

1. temperaturecooled
2. washwashed with water
3. customThe organic layer was separated
4. customdried
5. additionwas treated with diethyl ether
6. customto give a solid
7. customRecrystallization of this material