Potassium Carbonate → HCID 131712082, compound

HRID 1413954Notes

Reaction equation

HRID 1413954 reaction equation
[CH3:1][C:2]([NH2:6])([CH3:5])[C:3]#[CH:4].[C:7]([NH:12][C:13]1[CH:14]=[C:15]([O:19][C:20](Cl)=[O:21])[CH:16]=[CH:17][CH:18]=1)([O:9][CH2:10][CH3:11])=[O:8].C(=O)([O-])[O-].[K+].[K+]>O>[CH2:10]([O:9][C:7](=[O:8])[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20](=[O:21])[NH:6][C:2]([CH3:5])([CH3:1])[C:3]#[CH:4])[CH:14]=1)[CH3:11]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 763193-Butyn-2-amine, 2-methyl-HCID 141306173-[(Ethoxycarbonyl)amino]phenyl carbonochloridate

Product 1

HCID 131712082HCID 131712082, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Into a solution of 5.0 g (0.06 mole) of 1,1-dimethypropinylamine in 30 ml acetic ester is dropped, after addition of 50 ml water, at 10° to 15° C., while stirring, a solution of 14.6 g (0.06 mole) chloroformic acid-3-(N-carbethoxyamino)-phenyl ester in 30 ml acetic ester and simultaneously a solution of 8.3 g (0.06 mole) potassium carbonate in 30 ml water, the reaction product crystallizing out. Stirring is continued for 30 minutes while cooling with ice. The product is suction-filtered and washed with ether and water.

Workup

  1. stirringStirring
  2. temperaturewhile cooling with ice
  3. filtrationThe product is suction-filtered
  4. washwashed with ether and water

Sources & evidence

ORD record
ord-7b087f77d9a845fba8b1920c8fc7ec52
Source dataset
uspto-grants-1981_02
Patent number
US04252557

Reaction notes

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