Benzoic Acid → HCID 12791331, compound

HRID 1413978Notes

Reaction equation

HRID 1413978 reaction equation
[CH3:1][O:2][C:3]([O:12][CH3:13])([O:10][CH3:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:14](O)(=O)[C:15]1C=CC=CC=1>>[CH3:13][O:12][C:3]1([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[O:10][CH:11]2[CH:1]([CH2:14][CH2:15]2)[O:2]1

Participants

3

Reactant 2

HCID 243Benzoic AcidHCID 69720Trimethyl orthobeznoate

Product 1

HCID 12791331HCID 12791331, compoundYield 4,737.1%

Procedure

21.5 g (0.25 mol) of cyclobutane-cis-1,2-diol, 47.8 g (0.26 mol) of orthobenzoic acid trimethyl ester and 0.5 g of benzoic acid are heated to 100° to 150° C. in the course of 3 hours. The methanol which forms is distilled off continuously. The residue is subjected to fractional distillation and gives 40.0 g (78%) of 3-methoxy-3-phenyl-2,4-dioxa-bicyclo[3,2,0]heptane (stereoisomer mixture) of boiling point0.7 92°.

Workup

  1. distillationThe methanol which forms is distilled off continuously
  2. distillationThe residue is subjected to fractional distillation

Sources & evidence

ORD record
ord-e55989c9a8c646b6a76b9dbb016966ff
Source dataset
uspto-grants-1981_02
Patent number
US04252738

Reaction notes

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