Acetyl chloride → HCID 54233991, compound

HRID 1413983Notes

Reaction equation

HRID 1413983 reaction equation
C[O:2][C:3]1([CH3:10])O[CH:8]2[CH:5]([CH2:6][CH2:7]2)[O:4]1.C([Cl:14])(=O)C>>[Cl:14][C@@H:8]1[CH2:7][CH2:6][C@H:5]1[O:4][C:3](=[O:2])[CH3:10]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 12791329HCID 12791329, compound

Product 1

HCID 54233991HCID 54233991, compoundYield 84%

Procedure

28.9 g (0.2 mol) of 3-methoxy-3-methyl-2,4-dioxa-bicyclo[3,2,0]heptane (stereoisomer mixture) and 15.4 g (0.2 mol) of acetyl chloride are heated to the reflux for 5 hours. Distillation in vacuo gives 24.8 g (84%) of trans-1-chloro-2-acetoxy-cyclobutane. Boiling point19 79°, nD20 1.4473.

Workup

  1. temperaturereflux for 5 hours
  2. distillationDistillation in vacuo

Sources & evidence

ORD record
ord-ed7052004e0d4ac1b0a7803039312e93
Source dataset
uspto-grants-1981_02
Patent number
US04252738

Reaction notes

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