Hydrochloric Acid → HCID 20289427, compound

HRID 1414005Notes

Reaction equation

HRID 1414005 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[O:12][CH2:13][C:14]([NH:16][O:17][CH3:18])=[O:15].NN.[ClH:21]>CO>[ClH:21].[NH2:3][O:12][CH2:13][C:14]([NH:16][O:17][CH3:18])=[O:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 9321HydrazineHCID 20289422HCID 20289422, compound

Product 1

HCID 20289427HCID 20289427, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Procedure

2.5 g of [(1,3-Dihydro-1,3-dioxo-2H isoindole-2-yl)oxy]-N-(methoxy) acetamide made as in Example 2(a) is dissolved in 50 ml CH3OH at 0° C. with stirring. A solution of 0.35 g hydrazine in 10 ml methanol is added and stirring at 0° C. is continued for 12 hours. After this time an equivalent amount of hydrochloric acid in 5 ml CH3OH is added and the precipitate formed is filtered off. The mother liquor is evaporated to dryness and 2-(aminooxy)-N-(methoxy)acetamide, hydrochloride as a residual oil is formed and used in the next step without further purification.

Workup

  1. stirringstirring at 0° C.
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customThe mother liquor is evaporated to dryness

Sources & evidence

ORD record
ord-45749ec659ed4fb2925468b8ab1fda29
Source dataset
uspto-grants-1981_02
Patent number
US04252802

Reaction notes

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