creatinine → HCID 131712087, compound

HRID 1414031Notes

Reaction equation

HRID 1414031 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([NH:15][CH2:16][CH2:17][O:18][CH3:19])=[O:14])[CH:11]=2)[NH:6][CH:5]=1.CN1C(N)=N[C:23](=[O:24])[CH2:22]1.S(=O)(=O)(O)O.O.[CH2:34]([OH:36])C>>[CH3:19][O:18][CH2:17][CH2:16][NH:15][C:13]([C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[NH:6][CH:5]=[C:4]2[CH2:3][CH2:2][NH:1][C:34](=[O:36])[O:24][CH2:23][C:22]1[CH:11]=[CH:12][CH:4]=[CH:3][CH:2]=1)=[O:14]

Participants

6

Reactant 5

HCID 588creatinineHCID 702EthanolHCID 962WaterHCID 1118Sulfuric AcidHCID 20289475HCID 20289475, compound

Product 1

HCID 131712087HCID 131712087, compound

Procedure

(ii)f [2-[5-[[(2-Methoxyethyl)amino]carbonyl]-1H-indol-3-yl]ethyl]carbamic acid, phenylmethyl ester (2.0 g) gave 3-(2-aminoethyl)-N-(2-methoxyethyl)-1H-indole-5-carboxamide, compound with creatinine, sulphuric acid and water (1:1:1:2) (0.8 g) as a white crystalline solid m.p. 193°-5° C. (from aqueous ethanol)

Sources & evidence

ORD record
ord-9cf4c3dffe694df3a5813be1e27967f6
Source dataset
uspto-grants-1981_02
Patent number
US04252803

Reaction notes

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