HCID 86737513, compound → HCID 86737512, compound

HRID 1414033Notes

Reaction equation

HRID 1414033 reaction equation
CN(CC[C:12]1[NH:13][C:14]2[C:19]([CH:20]=1)=[CH:18][C:17]([C:21]([NH2:23])=[O:22])=[CH:16][CH:15]=2)CC1C=CC=CC=1>C(O)C>[CH2:21]([OH:22])[CH3:17].[CH3:14][NH:13][CH2:12][CH2:20][C:20]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:21]([NH2:23])=[O:22])[CH:18]=2)[NH:13][CH:12]=1

Participants

3

Reactant 1

HCID 86737513HCID 86737513, compound

Product 1

HCID 86737512HCID 86737512, compoundYield 155.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-[2-[(methyl(phenylmethyl)amino]ethyl]-1H-indole-5-carboxamide (1.05 g) in absolute ethanol (200 ml) was hydrogenated over pre-reduced palladium oxide on charcoal (10%, 0.5 g) for 2.5 hours at room temperature and pressure. The catalyst was filtered off and the filtrate evaporated in vacuo to give the title compound (0.7 g) as a colourless crystalline solid. T.L.C. Silica, ethanol:water (1:1) Rf 0.3

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-7a9d99a6d2bf4b01ae321d9339d61636
Source dataset
uspto-grants-1981_02
Patent number
US04252803

Reaction notes

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