Hydrochloric Acid → HCID 20289599, compound

Participants

Reaction Steps

A solution of 1.1 g. (5 mmole) of 8-chloro-2,3,4,5-tetrahydro-1H-1,4-diazepino[17-a]benzimidazole prepared in Example 1 above, 0.85 g. (5 mmole) 1-iodopropane, and 0.75 g. (7.5 mmole) of sodium carbonate in 100 ml. of 95% ethanol is refluxed 72 hours. After removing the solvent in vacuo, the residue is chromatographed over silica gel, eluting with hexane/chloroform saturated with ammonia (1:4). The product obtained is dissolved in absolute ethanol and acidified with ethanolic hydrochloric acid. The crystals which separate are filtered and dried to afford 0.41 g. (25%) of the dihydrochloride salt: m.p. 271°-274° C.

Provenance & Evidence