Nitric Acid → HCID 54176741, compound

HRID 1414051Notes

Reaction equation

HRID 1414051 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH:5]1([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[C:13]([OH:21])[CH:12]=2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>C(Cl)Cl>[CH:5]1([C:11]2[C:16]([N+:1]([O-:4])=[O:2])=[CH:15][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[C:13]([OH:21])[CH:12]=2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 21447337HCID 21447337, compound

Product 1

HCID 54176741HCID 54176741, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.06 ml of 100% nitric acid are slowly added dropwise at -10° to a solution of 5.9 g of 4-cyclohexyl-2-hydroxy-phenylacetic acid in 100 ml of absolute methylene chloride. The mixture is finally stirred for 10 minutes without further cooling, the methylene chloride solution washed several times with water, dried over sodium sulphate and evaporated to yield the title compound.

Workup

  1. washthe methylene chloride solution washed several times with water
  2. dry with materialdried over sodium sulphate
  3. customevaporated

Sources & evidence

ORD record
ord-0718a6c7756b4a7e9a03faafa529caac
Source dataset
uspto-grants-1981_02
Patent number
US04252817

Reaction notes

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