Succinimide → HCID 20158185, compound

HRID 1414052Notes

Reaction equation

HRID 1414052 reaction equation
[Cl:1]N1C(=O)CCC1=O.C1(=O)NC(=O)CC1.[CH:16]1([C:22]2[CH:27]=[CH:26][C:25]([CH2:28][C:29]([OH:31])=[O:30])=[C:24]([OH:32])[CH:23]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>C(Cl)Cl>[Cl:1][C:27]1[C:22]([CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)=[CH:23][C:24]([OH:32])=[C:25]([CH2:28][C:29]([OH:31])=[O:30])[CH:26]=1

Participants

5

Reactant 3

HCID 11439SuccinimideHCID 31398ChlorosuccinimideHCID 21447337HCID 21447337, compound

Product 1

HCID 20158185HCID 20158185, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.54 g of N-chlorosuccinimide and 5.25 g of succinimide are added to a solution of 6.2 g of 4-cyclohexyl-2-hydroxy-phenylacetic acid in 200 ml of dry methylene chloride and the mixture left to react for 5 days at room temperature. The clear reaction solution is washed twice with 1 N hydrochloric acid and once with water, dried and evaporated. The white crystalline residue can either be worked up directly or purified by recrystallization from methylene chloride/petroleum ether.

Workup

  1. waitthe mixture left
  2. customto react for 5 days at room temperature
  3. washThe clear reaction solution is washed twice with 1 N hydrochloric acid and once with water
  4. customdried
  5. customevaporated
  6. custompurified by recrystallization from methylene chloride/petroleum ether

Sources & evidence

ORD record
ord-d47ba97a7f8d40aabf1a92b6950a5c59
Source dataset
uspto-grants-1981_02
Patent number
US04252817

Reaction notes

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