Potassium Hydroxide → HCID 70393882, compound

HRID 1414063Notes

Reaction equation

HRID 1414063 reaction equation
[OH-].[K+].Br.[CH3:4][O:5][C@@H:6]1[CH2:11][CH2:10][CH2:9][NH:8][C@H:7]1[CH2:12][C:13](=[O:15])[CH3:14]>>[CH3:4][O:5][C@@H:6]1[CH2:11][CH2:10][CH2:9][NH:8][C@H:7]1[CH2:12][C:13](=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 86737518HCID 86737518, compound

Product 1

HCID 70393882HCID 70393882, compoundYield 99.7%

Procedure

250 g of potassium hydroxide were added to a solution of 500 g of trans (3-methoxy-2-piperidyl)-2-propanone hydrobromide in 500 ml of ice water and the mixture was extracted with methylene chloride. The combined organic phases were dried, treated with 25 g of carbon black and evaporated to dryness under reduced pressure to obtain 338.5 g of trans (3-methoxy-2-piperidyl)-2-propanone in the form of an oil which was used as is for the next step.

Workup

  1. extractionthe mixture was extracted with methylene chloride
  2. customThe combined organic phases were dried
  3. additiontreated with 25 g of carbon black
  4. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-b8d751d8e9d44fdaaac69154ea465189
Source dataset
uspto-grants-1981_02
Patent number
US04252947

Reaction notes

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