Hydrogen Bromide → HCID 86737518, compound

HRID 1414064Notes

Reaction equation

HRID 1414064 reaction equation
[CH3:1][O:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][NH:5][C@H:4]1[CH2:9][C:10](=[O:12])[CH3:11].[BrH:13]>>[BrH:13].[CH3:1][O:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][NH:5][C@H:4]1[CH2:9][C:10](=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 70393882HCID 70393882, compound

Product 1

HCID 86737518HCID 86737518, compoundYield 104.3%

Procedure

A mixture of 38.7 g of the product of Step A3 in 160 ml of an isopropanolic solution titrating 15.5 g of hydrobromic acid per 100 ml was held at 20° C. for 30 minutes and was then vacuum filtered. The recovered product was washed with isopropanol and was dried at 40° C. to obtain 50.4 g of trans (3-methoxy-2-piperidyl)-2-propanone hydrobromide with a melting point of 196° C. and a specific rotation of [α]D20 =+41°±(c=1% in methanol).

Workup

  1. filtrationvacuum filtered
  2. washThe recovered product was washed with isopropanol
  3. customwas dried at 40° C.

Sources & evidence

ORD record
ord-a8a983f6b3904989aaa3db46c25c3a89
Source dataset
uspto-grants-1981_02
Patent number
US04252947

Reaction notes

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