Acetate-hydrochloric acid → HCID 70632897, compound

HRID 1414178Notes

Reaction equation

HRID 1414178 reaction equation
C(OC([CH:8]([NH2:33])[CH2:9][C:10]([N:12]1[C:16](=[O:17])[CH2:15][N:14]([N:18]=[CH:19][C:20]2[O:24][C:23]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)=[CH:22][CH:21]=2)[C:13]1=[O:32])=[O:11])=O)(C)(C)C.[ClH:34].C(O)(=O)C>>[ClH:34].[NH2:33][CH2:8][CH2:9][C:10]([N:12]1[C:16](=[O:17])[CH2:15][N:14]([N:18]=[CH:19][C:20]2[O:24][C:23]([C:25]3[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=3)=[CH:22][CH:21]=2)[C:13]1=[O:32])=[O:11]

Participants

3

Reactant 2

HCID 22641269Acetate-hydrochloric acidHCID 70633446HCID 70633446, compound

Product 1

HCID 70632897HCID 70632897, compound

Procedure

The 3-(t-butoxycarbonyl-aminopropionyl)-1-{[5-(4-fluorophenyl) furfurylidene]amino}hydantoin (10.4 g, 0.023 mole) was added to 3% HCl/acetic acid (125 ml) and stirred for 4 hours. The yellow solid was filtered, washed with nitromethane and ether to yield 7 g, 28%, m.p. 195°-197° C.

Workup

  1. filtrationThe yellow solid was filtered
  2. washwashed with nitromethane and ether
  3. customto yield 7 g, 28%, m.p. 195°-197° C.

Sources & evidence

ORD record
ord-a887c4e7cb5646fc985d3c5bff4dbcf1
Source dataset
uspto-grants-1977_01
Patent number
US04001222

Reaction notes

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