反应详情

10 g ethyl S-(4,5-diphenyloxazol-2-yl)-mercaptoacetate dissolved in 30 ml ethanol were mixed with 30 ml 40% NaOH and maintained for 1 hour at room temperature. The sodium salt which separated from the reaction mixture was redissolved by means of addition of 200 ml distilled water. The alkaline solution was slowly poured into 300 ml ice-cooled 15% HCl. The precipitated S-(4,5-diphenyloxazol-2-yl)-mercaptoacetic acid was filtered, washed with water and crystallized from aqueous ethanol to give 7.4 g of a product melting at 137°-139° C (yield = 80.7%).

1. customThe sodium salt which separated from the reaction mixture
2. dissolutionwas redissolved by means of addition of 200 ml
3. distillationdistilled water
4. additionThe alkaline solution was slowly poured into 300 ml ice-
5. temperaturecooled 15% HCl
6. filtrationThe precipitated S-(4,5-diphenyloxazol-2-yl)-mercaptoacetic acid was filtered
7. washwashed with water
8. customcrystallized from aqueous ethanol