HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1414224Generated: October 26, 2026
2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(3-methylisoxazole-5-carbonyl)-piperazin-1-yl]quinazoline Hydrochloride
https://huagongshe.com/reaction/1414224
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline | HCID 616267 | — |
| Reactant | 3-Methyl-1,2-oxazole-5-carbonyl chloride | HCID 12905099 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Amino-6,7-dimethoxy-2-[4-(3-methylisoxazole-5-carbonyl)-piperazin-1-yl]quinazoline Hydrochloride | HCID 21183935 | — |
Reaction Steps
A solution of 3-methylisoxazole-5-carbonyl chloride (0.73 g., 5.02 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl) quinazoline (1.45 g., 5.02 mmole) in dioxane. The mixture was heated briefly, then was stirred at 20° C. for 2.5 hours. Workup as in Example 1 gave the title compound having a m.p. of 263°-264° C. with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04001237 |
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| Source dataset | uspto-grants-1977_01 |
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| ORD ID | ord-126daae7075640dd963adada60bbb65c |
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| Source note | uspto-grants-1977_01 |
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