2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(3-methylisoxazole-5-carbonyl)-piperazin-1-yl]quinazoline Hydrochloride

HRID 1414224Notes

Reaction equation

[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([Cl:9])=[O:8])[O:4][N:3]=1.[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>O1CCOCC1>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:5]3[O:4][N:3]=[C:2]([CH3:1])[CH:6]=3)=[O:8])[CH2:27][CH2:26]2)[N:12]=1

Participants

Conditions

Temperature: 20 °C

Procedure

A solution of 3-methylisoxazole-5-carbonyl chloride (0.73 g., 5.02 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl) quinazoline (1.45 g., 5.02 mmole) in dioxane. The mixture was heated briefly, then was stirred at 20° C. for 2.5 hours. Workup as in Example 1 gave the title compound having a m.p. of 263°-264° C. with decomposition.

Workup

temperatureThe mixture was heated briefly

Sources & evidence

ORD record: ord-126daae7075640dd963adada60bbb65c
Source dataset: uspto-grants-1977_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04001237

Reaction notes

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