2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(2-methyloxazole-4-carbonyl)piperazin-1-yl]quinazoline Hydrochloride

HRID 1414226Notes

Reaction equation

HRID 1414226 reaction equation
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([Cl:9])=[O:8])[N:6]=1.[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>O1CCOCC1>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:5]3[N:6]=[C:2]([CH3:1])[O:3][CH:4]=3)=[O:8])[CH2:27][CH2:26]2)[N:12]=1

Participants

4

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 146590622-Methyl-1,3-oxazole-4-carbonyl chloride

Product 1

HCID 211840484-Amino-6,7-dimethoxy-2-[4-(2-methyloxazole-4-carbonyl)piperazin-1-yl]quinazoline Hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 2-methyloxazole-4-carbonyl chloride (1.01 g., 6.9 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.00 g., 6.9 mmole) in dioxane. The mixture was heated at reflux for 2 hours. Filtration gave the title compound having a m.p. of 278°-280° C. with decomposition after recrystallization from methanol.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 2 hours
  3. filtrationFiltration

Sources & evidence

ORD record
ord-a70699a76d9c4569a0c7e44273781520
Source dataset
uspto-grants-1977_01
Patent number
US04001237

Reaction notes

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