2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21183921, compound

HRID 1414227Notes

Reaction equation

HRID 1414227 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7]([Cl:9])=[O:8].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:6]3[O:5][CH:4]=[N:3][C:2]=3[CH3:1])=[O:8])[CH2:27][CH2:26]2)[N:12]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 27952174-Methyloxazole-5-carbonyl chloride

Product 1

HCID 21183921HCID 21183921, compound

Procedure

The title compound was prepared from 4-methyloxazole-5-carbonyl chloride (0.85 g.) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (1.68 g.) following the procedure of Example 1. The product had a m.p. of 283.5°-288° C. with decomposition.

Sources & evidence

ORD record
ord-c697353c21634778aacfe786fc382627
Source dataset
uspto-grants-1977_01
Patent number
US04001237

Reaction notes

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