2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21184056, compound

HRID 1414230Notes

Reaction equation

HRID 1414230 reaction equation
[S:1]1[C:5]([C:6]([Cl:8])=[O:7])=[CH:4][N:3]=[CH:2]1.[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[N:11]=1>>[ClH:8].[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][N:27]([C:6]([C:5]3[S:1][CH:2]=[N:3][CH:4]=3)=[O:7])[CH2:26][CH2:25]2)[N:11]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 224581411,3-Thiazole-5-carbonyl chloride

Product 1

HCID 21184056HCID 21184056, compound

Procedure

The title compound was prepared from thiazole-5-carbonyl chloride (0.77 g.) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (1.51 g.) following previously described procedures. The product had a m.p. of 280°-281° C. with decomposition.

Sources & evidence

ORD record
ord-a7245a3fa6b440b09b5ea8760b65846a
Source dataset
uspto-grants-1977_01
Patent number
US04001237

Reaction notes

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