2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(5-n-propylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quinazoline hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline	HCID 616267	—
Reactant	5-(Propylsulfanyl)-1,3,4-oxadiazole-2-carbonyl chloride	HCID 21183940	—
Product	4-Amino-6,7-dimethoxy-2-[4-(5-n-propylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quinazoline hydrochloride	HCID 21184036	—

Reaction Steps

The title compound was prepared from 5-n-propylthio-1,3,4-oxadiazole-2-carbonyl chloride (1.68 g., 8.16 mmole) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.36 g., 8.16 mmole) following the procedure of Example 1. The product had a M.P. of 230°-245° C. with decomposition.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04001238
Source dataset	uspto-grants-1977_01
ORD ID	ord-889be0568fe34226a312f3d53d513e49
Source note	uspto-grants-1977_01