2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(5-n-propylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quinazoline hydrochloride

HRID 1414241Notes

Reaction equation

HRID 1414241 reaction equation
[CH2:1]([S:4][C:5]1[O:9][C:8]([C:10]([Cl:12])=[O:11])=[N:7][N:6]=1)[CH2:2][CH3:3].[NH2:13][C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[C:16]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[N:15]=1>>[ClH:12].[NH2:13][C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[C:16]([N:28]2[CH2:33][CH2:32][N:31]([C:10]([C:8]3[O:9][C:5]([S:4][CH2:1][CH2:2][CH3:3])=[N:6][N:7]=3)=[O:11])[CH2:30][CH2:29]2)[N:15]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 211839405-(Propylsulfanyl)-1,3,4-oxadiazole-2-carbonyl chloride

Product 1

HCID 211840364-Amino-6,7-dimethoxy-2-[4-(5-n-propylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quinazoline hydrochloride

Procedure

The title compound was prepared from 5-n-propylthio-1,3,4-oxadiazole-2-carbonyl chloride (1.68 g., 8.16 mmole) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.36 g., 8.16 mmole) following the procedure of Example 1. The product had a M.P. of 230°-245° C. with decomposition.

Sources & evidence

ORD record
ord-889be0568fe34226a312f3d53d513e49
Source dataset
uspto-grants-1977_01
Patent number
US04001238

Reaction notes

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