Diisobutylaluminumhydride → 8-Methyl-8-azabicyclo(3.2.1)octan-3-ol

HRID 1414348Notes

Reaction equation

HRID 1414348 reaction equation
[C:1]([N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH2:7][C:8](=[O:13])[CH2:9]2)(OC)=O.[H-].C([Al+]CC(C)C)C(C)C>C1C=CC=CC=1>[CH3:1][N:5]1[CH:10]2[CH2:9][CH:8]([OH:13])[CH2:7][CH:6]1[CH2:12][CH2:11]2

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 21487037HCID 21487037, compound

Product 1

HCID 84248-Methyl-8-azabicyclo(3.2.1)octan-3-ol

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A process as claimed in claim 8, wherein N-carbomethoxy-8-azabicyclo (3,2,1) octan-3-one is reacted with diisobutyl-aluminumhydride in benzene and at room temperature, to produce tropine.

Sources & evidence

ORD record
ord-e1d313f46bdc468b8ee12843374c4a66
Source dataset
uspto-grants-1977_01
Patent number
US04001249

Reaction notes

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