Triethylamine → HCID 21487069, compound

HRID 1414353Notes

Reaction equation

HRID 1414353 reaction equation
C([N:3]([CH2:6][CH3:7])CC)C.Cl[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][N:10]=1>C(O)C>[CH2:6]([NH:3][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][N:10]=1)[CH2:7][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 783082-Chloro-5-nitropyridine

Product 1

HCID 21487069HCID 21487069, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

101 g of triethylamine and subsequently 50 g of n-hexylamino are placed into 600 ml of distilled anhydrous ethanol. An amount of 79 g of 2-chloro-5-nitropyridine is added portionwise at room temperature in the course of 15 minutes. The mixture is then heated to reflux temperature, whereby it goes into solution at 60° C. The solution is stirred for 24 hours at the reflux temperature and afterwards cooled to room temperature; the solution is poured into ice/water, and the formed precipitate filtered off. The 2-n-hexylamino-5-nitropyridine obtained after recrystallisation from ethanol/water melts at 56°-57° C.

Workup

  1. temperatureThe mixture is then heated
  2. temperatureto reflux temperature, whereby it
  3. customgoes into solution at 60° C
  4. filtrationthe formed precipitate filtered off

Sources & evidence

ORD record
ord-8cc533027ad54b549f27f9a441dae452
Source dataset
uspto-grants-1977_01
Patent number
US04001254

Reaction notes

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