Bromide ion → HCID 21507434, compound

HRID 1414518Notes

Reaction equation

[CH3:1][C:2](=[CH2:5])[CH2:3]Cl.[Br-].[C:7]1([N:13]2[C:19]3[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=3[NH:17][C:16](=[O:25])[CH2:15][C:14]2=[O:26])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[C:7]1([N:13]2[C:19]3[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=3[N:17]([CH2:3][C:2]([CH3:5])=[CH2:1])[C:16](=[O:25])[CH2:15][C:14]2=[O:26])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

Reactant 3

HCID 259Bromide ion

HCID 112413-Chloro-2-methyl-1-propene

HCID 89657Desmethylclobazam

Product 1

HCID 21507434HCID 21507434, compound

Procedure

In the same manner by acting (2'-methylallyl) chloride or bromide in the presence of a metallation agent, starting from 1-phenyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine, there is obtained 1-phenyl 5-(2'-methylallyl) 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine (R1 = H, R2 = Cl R3 = ##STR20## R4 = C6H5) melting at 149°-151° C upon recrystallisation in 50 % ethanol.

Sources & evidence

ORD record: ord-c75661b6ef5b4b1481b6fa8617a4f6cc
Source dataset: uspto-grants-1977_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04001408

Reaction notes

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