Hydrogen Bromide → HCID 70579172, compound

HRID 1414558Notes

Reaction equation

HRID 1414558 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]2([C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([O:27]C)[C:21]=3[O:20][C:19]3[C:14]2=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br>C(O)(=O)C>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]2([C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([OH:27])[C:21]=3[O:20][C:19]3[C:14]2=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 70577346HCID 70577346, compound

Product 1

HCID 70579172HCID 70579172, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1'-Benzyl-4-methoxyxanthene-9-spiro-4'-piperidine is demethylated using 45% w/v hydrobromic acid in glacial acetic acid as described in Example 4 to give 1'-benzyl-4-hydroxyxanthene-9-spiro-4'-piperidine converted to its hydrochloride, m.p. 164° C. on recrystallisation from ethanol-ether.

Sources & evidence

ORD record
ord-894bb770092f47a38177ca2b5fb26369
Source dataset
uspto-grants-1977_01
Patent number
US04001419

Reaction notes

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