Methylamine → 1-Cyclopropyl-3-(methylamino)propan-1-one

HRID 1414577Notes

Reaction equation

HRID 1414577 reaction equation
[CH:1]1([C:4](=[O:10])[CH2:5][CH2:6][N:7](C)[CH3:8])[CH2:3][CH2:2]1.CN>C1C=CC=CC=1>[CH:1]1([C:4](=[O:10])[CH2:5][CH2:6][NH:7][CH3:8])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 2319851-cyclopropyl-3-(dimethylamino)propan-1-one

Product 1

HCID 214880801-Cyclopropyl-3-(methylamino)propan-1-one

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 42.5 g. (0.3 mole) of 1-cyclopropyl-3-dimethylamino-1-propanone in 200 ml. of benzene was refluxed while methylamine was bubbled through the solution for eight hours. The nuclear magnetic resonance spectrum indicated a 90% conversion to 1-cyclopropyl-3-methylamino-1-propanone.

Workup

  1. customwas bubbled through the solution for eight hours

Sources & evidence

ORD record
ord-269e87be2f294a318a0537e831eb82da
Source dataset
uspto-grants-1977_01
Patent number
US04001429

Reaction notes

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