Acetic Anhydride → HCID 21488089, compound

HRID 1414578Notes

Reaction equation

HRID 1414578 reaction equation
[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][NH:7][CH3:8])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].C(O[C:20](=[O:22])[CH3:21])(=O)C>>[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][N:7]([CH3:8])[C:20](=[O:22])[CH3:21])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 214880801-Cyclopropyl-3-(methylamino)propan-1-one

Product 1

HCID 21488089HCID 21488089, compound

Procedure

A crude solution of 1-cyclopropyl-3-methylamino-1-propanone was cooled to 8°-10° C. and 8.2 g. (0.06 mole) of potassium carbonate was added, followed by 50 g. (0.5 mole) of acetic anhydride. The mixture was stirred until it warmed to room temperature. The benzene layer was separated, dried over magnesium sulfate, concentrated, and the residual oil distilled at 99°-150° C./0.1 mm. The distillate weighed 65 g. It was calculated to contain 80% of 1-cyclopropyl-3-(N-methylacetamido)-1-propanone by the nuclear magnetic resonance spectrum.

Workup

  1. customThe benzene layer was separated
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. distillationthe residual oil distilled at 99°-150° C./0.1 mm

Sources & evidence

ORD record
ord-31ac4865f75c4e69aa429f84cfffca63
Source dataset
uspto-grants-1977_01
Patent number
US04001429

Reaction notes

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