Triethylamine → HCID 70638606, compound

HRID 1414589Notes

Reaction equation

HRID 1414589 reaction equation
[OH:1][CH2:2][C:3]1[S:4][C:5]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][N:7]=1.[Cl:12][C:13]1[CH:25]=[CH:24][C:16]([O:17][C:18]([CH3:23])([CH3:22])[C:19](Cl)=[O:20])=[CH:15][CH:14]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[Cl:12][C:13]1[CH:25]=[CH:24][C:16]([O:17][C:18]([CH3:22])([CH3:23])[C:19]([O:1][CH2:2][C:3]2[S:4][C:5]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][N:7]=2)=[O:20])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27813122-(4-Chlorophenoxy)-2-methylpropanoyl chlorideHCID 21488103HCID 21488103, compound

Product 1

HCID 70638606HCID 70638606, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Using the procedure of Example 3, methyl 2-hydroxymethyl-thiazole-5-carboxylate and p-chlorophenoxy-isobutyric acid chloride were reacted in toluene and triethylamine to obtain methyl 2-[α-(p-chlorophenoxy)-α,α-dimethylacetoxymethyl]-thiazole-5-carboxylate melting at 80° C.

Sources & evidence

ORD record
ord-d62e99890d924f67b50d670b8491a855
Source dataset
uspto-grants-1977_01
Patent number
US04001447

Reaction notes

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