2-Chloro-N,N-dimethylethylamine → HCID 21488015, compound

HRID 1414624Notes

Reaction equation

HRID 1414624 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:27]=[CH:26][CH:25]=[CH:24][C:11]=3[C:12]=2[C:13](=[O:23])[C:14]2[CH:19]=[C:18]([CH3:20])[C:17]([CH3:21])=[C:16]([CH3:22])[CH:15]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:34][N:35]([CH3:39])[CH2:36][CH2:37]Cl>CC(C)=O>[CH3:34][N:35]([CH3:39])[CH2:36][CH2:37][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:27]=[CH:26][CH:25]=[CH:24][C:11]=3[C:12]=2[C:13](=[O:23])[C:14]2[CH:19]=[C:18]([CH3:20])[C:17]([CH3:21])=[C:16]([CH3:22])[CH:15]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 79012-Chloro-N,N-dimethylethylamineHCID 11430Potassium CarbonateHCID 21487908HCID 21487908, compound

Product 1

HCID 21488015HCID 21488015, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-p-Hydroxyphenyl-3-(3',4',5'-trimethylbenzoyl)benzofuran (5.4 g., 15.3 mmol.) was dissolved in 200 ml. of dry acetone and 10.5 g. (0.076 mol.) of potassium carbonate and 2.10 g. (15.3 mmol.) of 2-dimethylaminoethyl chloride were added. The reaction mixture was refluxed for three hours, then it was cooled and filtered. The filtrate was concentrated under reduced pressure to give the title compound.

Workup

  1. temperatureThe reaction mixture was refluxed for three hours
  2. temperatureit was cooled
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-60bbd14f6f194057af6699315e7a1d2a
Source dataset
uspto-grants-1977_01
Patent number
US04001426

Reaction notes

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