反应详情

A mixture of 2-methylthio-4H-3,1-benzothiazine (48.8 g, 0.25 mole) and 5-chloro-2,4-dimethoxyaniline (46.8 g, 0.25 mole) in n-butanol (200 ml) was refluxed overnight. After cooling in ice, the solid was collected by filtration and recrystallized from ethanol to give 36 g (43.4%) of product. Recrystallization from ethanol gave an analytical sample, m.p. 157°-158°.

1. temperaturewas refluxed overnight
2. temperatureAfter cooling in ice
3. filtrationthe solid was collected by filtration
4. customrecrystallized from ethanol