HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2,4-dimethoxyaniline → N-(5-Chloro-2,4-dimethoxyphenyl)-4H-3,1-benzothiazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2,4-dimethoxyaniline | HCID 66807 | — |
| Reactant | 2-(Methylsulfanyl)-4H-3,1-benzothiazine | HCID 21484890 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | N-(5-Chloro-2,4-dimethoxyphenyl)-4H-3,1-benzothiazin-2-amine | HCID 21484882 | 43.4% |
Reaction Steps
A mixture of 2-methylthio-4H-3,1-benzothiazine (48.8 g, 0.25 mole) and 5-chloro-2,4-dimethoxyaniline (46.8 g, 0.25 mole) in n-butanol (200 ml) was refluxed overnight. After cooling in ice, the solid was collected by filtration and recrystallized from ethanol to give 36 g (43.4%) of product. Recrystallization from ethanol gave an analytical sample, m.p. 157°-158°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002620 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-8559823372844f3ba41e18373ab28585 |
| Source note | uspto-grants-1977_01 |