HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Ethyl-4-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride | HCID 11183940 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-Ethyl-4-methylpiperazine | HCID 12229105 | 250.2% |
Reaction Steps
A solution of 3.75 g of raubasinic acid hydrochloride in 100 ml of anhydrous isopropanol in the presence of 3.20 g of anhydrous sodium carbonate is heated under reflux with agitation and in nitrogen atmosphere with 2.35 g of 1-methyl-4β chlorethylpiperazine dihydrochloride. After 4 hours the mixture is treated as in Example 1. One obtains 3.2 g of 1-methyl-4β ethylpiperazine raubasinate hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002633 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-5e4d376b80854210b71fe7a528f84898 |
| Source note | uspto-grants-1977_01 |