Hydrochloric Acid → 1-Ethyl-4-methylpiperazine

HRID 1414718Notes

Reaction equation

HRID 1414718 reaction equation
Cl.C(=O)([O-])[O-].[Na+].[Na+].Cl.Cl.[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18]Cl)[CH2:13][CH2:12]1>C(O)(C)C>[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH3:18])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 111839401-(2-Chloroethyl)-4-methylpiperazine dihydrochloride

Product 1

HCID 122291051-Ethyl-4-methylpiperazineYield 250.2%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 3.75 g of raubasinic acid hydrochloride in 100 ml of anhydrous isopropanol in the presence of 3.20 g of anhydrous sodium carbonate is heated under reflux with agitation and in nitrogen atmosphere with 2.35 g of 1-methyl-4β chlorethylpiperazine dihydrochloride. After 4 hours the mixture is treated as in Example 1. One obtains 3.2 g of 1-methyl-4β ethylpiperazine raubasinate hydrochloride.

Workup

  1. additionAfter 4 hours the mixture is treated as in Example 1

Sources & evidence

ORD record
ord-5e4d376b80854210b71fe7a528f84898
Source dataset
uspto-grants-1977_01
Patent number
US04002633

Reaction notes

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