Thiophenol → HCID 571485, compound

HRID 1414856Notes

Reaction equation

HRID 1414856 reaction equation
[C:1]([NH:4][C:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(SC)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2].[C:17]1(S)C=CC=CC=1.C(N(CC)CC)C>CO>[C:1]([NH:4][CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8][CH3:17])=[O:7])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 8471TriethylamineHCID 21485357N-acetylamino-alpha-methylthiophenylacetic acid

Product 1

HCID 571485HCID 571485, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

173 Milligrams of a methanethiol ester of α-acetylamino-α-methylthiophenylacetic acid and 50 mg of thiophenol were dissolved in 10 ml of methanol. To the solution 1 ml of triethylamine was added, and the system was refluxed for 1.5 hours. Concentrating the reaction mixture under reduced pressure, the residue was parted by a column chromatography (silica gel and methylene chloride). Thus 127 mg of methyl α-acetylaminophenylacetate was obtained.

Workup

  1. temperaturethe system was refluxed for 1.5 hours
  2. concentrationConcentrating the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-b58518220d3d403c973c7a4addf16d19
Source dataset
uspto-grants-1977_01
Patent number
US04002682

Reaction notes

Loading…